The ancient city of Zeugma on the banks of the Euphrates in Turkey, was partially flooded in 2000 by the new Birecik dam. In May of 2000, the Packard Humanities Institute (PHI), in coordination with authorities of the Turkish Ministry of Culture, initiated an international rescue program based on a "targeted" archaeological investigation and a plan for conservation in situ: the Zeugma Archaeological Project (ZAP 2000); this was an emergency operation intended to increase topographical knowledge of the city and safeguard the finds before total flooding. The program also involved the restoration of everything that had been excavated and removed from Zeugma in the course of previous digs. The CCA, Centro di Conservazione Archeologica, was asked to plan and implement the conservation and restoration program. Starting in July 2000 through November of the same year, a group of 25 professional Italian and Turkish conservators carried out the program during and after the archaeological excavation. Subsequently, the same group worked on the restoration of 800 m2 of mosaics removed from Zeugma. The volume describes the various operations performed, with particular reference to the mosaics.